Health Supernova 2022 Health Supernova 2022

Room 104B

Tuesday, May 10, 2022

- CDT
Lightning Talk | Precision Pain Therapeutics
Candler Paige
Candler Paige
Doloromics, CEO

“No pain, no gain” is meant to console and motivate. Yet, for millions who live with unrelenting debilitating conditions, they’d do anything to gain relief. Opioids can’t be the only answer. Every day in America, three people die every hour from opioid overdose. Prescription opioid misuse alone costs the U.S. $78.5B a year for healthcare, addiction treatment, and more. Physicians need other options and other prospects to help patients manage their pain.

CEO Candler Paige is on a mission to help. Her company, Doloromics, is building a proprietary platform for discovery of disease-specific pain mechanisms, biomarkers, and therapeutics to treat inflammatory and chronic pain. It will be a game-changer for getting quick chronic pain relief to patients who suffer from migraine, muscle pain, and neuropathies — common problems that require uncommon solutions.

- CDT
Lightning Talk | Platform Approaches to Combating Diseases
Benjamin M. Greenberg
Benjamin M. Greenberg
UT Southwestern, Professor of Neurology
David Greenberg
David Greenberg
UT Southwestern, Professor, Infectious Diseases and Microbiology

What began as endless battles with action figures is now an endless and inspiring crusade to prevent and fight disease. In this Lightning Talk, two brothers at UTSW Medical Center —one an Infectious Disease expert trained at NIH, the other a Johns Hopkins-trained Neuroimmunologist—are on separate but driven paths.

Meet Dr. David Greenberg who is focused on commercializing precision pathogen-specific antibiotics to help tackle the worldwide crisis of antibiotic resistance. And learn about Dr. Ben Greenberg’s efforts for the Department of Neurology in treating rare autoimmune disorders of the central nervous system.

- CDT
Lightning Talk | Reviving the Wooly Mammoth
Brandi Cantarel
Brandi Cantarel
Colossal, Associate Director of Bioinformatics

How are the genomes of mammoths different from their closest living relatives? And what genetic changes impact physical and adaptive traits? These are the types of questions bioinformaticians seek to answer by using next-gen tools to help design, execute, and validate biological experiments. And they’re questions that Brandi Cantarel and Colossal are answering to turn back time and revive the wooly mammoth. But it's not just about the species; this set of tools can be used for many purposes, whether it’s de-extinction or re-coding the human genome

In this quick talk, Brandi will outline how Colossal is pioneering CRISPR technology for the purposes of species de-extinction, beginning with the wooly mammoth. She and her team are combining the science of genetics with the business of discovery in an endeavor to jumpstart nature’s ancestral heartbeat and advance the economies of biology and healing through genetics. 

- CDT
Lightning Talk | Ending the Antibiotic Abuse presented by University of North Texas Health Science Center at Fort Worth
Joe Skraba
Joe Skraba
Entvantage Diagnostics, Inc., Co-Founder, President and CEO

80% of patients are prescribed antibiotics for sinusitis, yet 90% of the time, sinusitis is caused by a viral infection that is untreatable by antibiotics. Together Entvantage Dx can reduce the use of antibiotics for ear, nose, and throat illnesses. Entvantage Dx diagnostic tests accurately distinguish bacterial from viral infections, reducing the unnecessary prescription of antibiotics. Joe Skraba will talk about their revolutionary diagnostic kit can qualitatively identify the three major bacterial sinusitis pathogens and provide differentiation from viral sinusitis infections. This determination allows the physician to only prescribe antibiotic treatment for patients who have bacterial sinusitis. 

- CDT
Social Determinants of Health in the Age of Digital Health Care presented by BlueCross BlueShield of Texas | C1 Innovation Lab
Claire Aldridge
Claire Aldridge
Taysha Gene Therapies, Senior Vice President
Madhuri Bobba
Madhuri Bobba
Senior Executive Medical Director, Blue Cross and Blue Shield of Texas

As technologies rise to improve healthcare, so too must our societal approaches to ensure all have equitable access to optimal healthcare, as well as access to key social and community services that contribute to positive health outcomes. 

All of us, from clinicians to business executives, technologists, and community leaders each play an important role in impacting the social determinants of our society. 

Join Dr. Madhuri Bobba and Dr. Claire Aldridge for a discussion about how technologies and social systems can work together to help people thrive in their health and lives.

- CDT
A Better Way to Treat Brain Tumors
Darin T. Okuda
Darin T. Okuda
UTSW Medical Center, Professor of Neurology, Director of Neuroinnovation

Weighing in at just three pounds, the human brain is the marvelous, mysterious source of everything that defines us as humans. It’s also been the modern medical mystery for centuries, and only in the last 10 years or so has scientific research yielded important insights and answers. Now, as technology development accelerates, exciting breakthroughs in neurological and behavioral science are possible.

That’s welcome news for more than 700,000 Americans living with a primary brain tumor. While most brain tumors are not malignant, the impact of treatment is likely life-changing. Dr. Darin Okuda and his team at UT Southwestern Neurology are working to change these realities, with a better way to diagnose and treat brain tumors using 3-D printing. As the keynote speaker for our Genesis of Prevention track at Health Supernova, presented by The University of Texas at Dallas and UT Southwestern Medical Center, Dr. Okuda will share how it works — and how it can scale.