North American Testis Workshop 2022

Program Chair: Wei Yan, MD, PhD
The Lundquist Institute at Harbor-UCLA/UCLA, Torrance, CA

Speaker:
Martin M. Matzuk, MD, PhD
Baylor College of Medicine, Houston, TX

8:00 am
Introduction
Chair:  Kate Loveland, PhD - Monash University and Hudson Institute, Melbourne, Australia

8:05 am
Lumicrine Factors in the Regulation of Spermatogenesis
Masahito Ikawa, PhD -Osaka University, Osaka, Japan

8:55 am
Introduction to Session I
Chairs: Erwin Goldberg, PhD - Northwestern University
Penny Whiley, Hudson Institute of Medical Research

9:00 am
Everything Old is New Again: Redefining Protamine Structure and Function
Sue Hammoud, PhD - University of Michigan, Ann Arbor, MI

9:40 am
Identification of a Novel Germ Cell Granule with Potential Roles in Meiotic Germ Cell Translation
Elizabeth Snyder, PhD - University of Rutgers, New Brunswick, NJ

10:20 am
BREAK

10:40 am
Pachytene piRNAs in Germ Cell Development
Chen Chen, PhD - Michigan State University, East Lansing, MI

11:20 am
Short Talk #1: TENT4A and TENT4B Control Poly(A) Tail Length and Non-A Contents in Murine Spermatogenic Cells
Zhuqing Wang, PhD - The Lundquist Institute at Harbor-UCLA, Torrence, CA

11:35 am
Short Talk #2: In Pro-Spermatogonia the RNA Binding Protein DND1 Targets Transcripts for Epigenetic, Cell Cycle, and Translation Regulation
Victor Ruthig, PhD - Duke University Medical Center, Durham, NC

1:10 pm
Introduction to Session II
Chairs: Jon Oatley, PhD, Washington State University
Tessa Lord, PhD - University of Newcastle 

1:15 pm
New Ideas on Fertility Preservation for People with Testes
Kyle Orwig, PhD - University of Pittsburgh, Pittsburgh, PA 

1:55 pm
What Spermatogonial Stem Cells Can Tell Us About Molecular Networks, Infertility, and Selfish DNA
Miles Wilkinson, PhD - University of California, San Diego

2:35 pm
BREAK

2:55 pm
Sperm-like Stem Cell-mediated Genome Editing
Jinsong Li, PhD - Chinese Academy of Sciences, Shanghai, China 

3:35 pm
Short Talk #3:  A Master Transcription Factor Influencing Both Pro-Spermatogonia and SSC Differentiation
Kun Tan, PhD - University of California, San Diego, San Diego, CA

3:50 pm
Short Talk #4:  Embryonic Origin of Testicular Macrophages
Andreas Meinhardt, PhD - Justus-Liebig University of Giessen, Giessen, Germany

8:00 am
Introduction
Chair:  Michael Griswold, PhD, Washington State University

8:05 am
Why is the Sperm Proteome Modified in the Female Reproductive Tract?
Mariana Wolfner, PhD - Cornell University, Ithaca, NY

8:55 am
Introduction to Session III
Chairs: Eirka Matunis, PhD, Johns Hopkins University
Hayden McSwiggin, PhD Candidate - The Lundquist Institute at Harbor-UCLA

9:00 am
New Insights into Sertoli Cell Fate Determination and Maintenance
Humphrey Yao, PhD - NIEHS, Research Triangle, NC

9:40 am
Epigenetic Regulation of Spermatogonial Stem Cell Specification
John McCarrey, MS, PhD - University of Texas, San Antonio, TX

10:20 am
BREAK

10:40 am

Some Assembly Required: How to Build a Meiotic DNA-Breaking Machine
Scott Keeney, PhD - Sloan Kettering Cancer Center, New York, NY

11:20 am
Short Talk #5:  Spatial Dynamics of Protein Translation in Sertoli Cells
Ana Cristina Lima, PhD - Oregon Health & Science University, Beaverton, OR

11:35 am
Short Talk #6:  Chromatin States During Spermatogonial Differentiation
Christine Schleif, Master Graduate Student - Washington State University, Pullman, WA

1:10 pm
Introduction to Session IV
Chairs: Qi Chen, MD, PhD, University of California - Riverside
Kien Tran, PhD Candidate, University of Pittsburgh

1:15 pm
Novel Transcription Factors Regulating Spermatogenesis
Prabhakara Reddi, PhD - University of Illinois Urbana-Champaign, Urbana, IL

1:55 pm
Testosterone Recovery Therapy Targeting Dysfunctional Leydig Cells
Vassilios Papadopoulos, PharmD, PhD - University of Southern California, Los Angeles, CA

2:35 pm
BREAK

2:55 pm
Follicle-Stimulating Hormone and D-cyclins Regulate Male Germ Cell Maintenance
T. Rajendra Kumar, PhD - University of Colorado, Aurora, CO

3:35 pm
Short Talk #7:  Leydig Cell Regeneration in Adult Mouse Testes
Jasmin Jeffrey, BS, PhD Candidate - Johns Hopkins University School of Medicine, Baltimore, MD

3:50 pm
Short Talk #8:  Higher Incidence of Embryonic Defects in Offspring Conceived by Assisted Reproduction from Fathers with Sperm Epimutations
Gurbet Karahan, PhD - McGill University, Montreal, QC, Canada

8:00 am
Introduction
Chair:  Monika Ward, PhD, University of Hawaii

8:05 am
Paternal Epigenome and Offspring Health
Jacquetta Trasler, MD, PhD - McGill University, Montreal, Canada

8:55 am
Introduction to Session V
Chairs: Wenfeng An, PhD, South Dakota State University
Jasmin Jeffery, PhD Candidate, Johns Hopkins University

9:00 am
Sperm-mediated Transgenerational Inheritance
Corrado Spadafora, PhD - National Research Council of Italy, Rome, Italy

9:40 am
Sperm RNA-mediated Epigenetic Inheritance
Isabelle Mansuy, Ph.D. - University and ETH Zurich, Zurich, Switzerland

10:20 am
BREAK

10:40 am
Short and Long-term Effects of Male Germline Reprogramming in the Absence of TET1
Marisa Bartolomei, PhD - University of Pennsylvania, Philadelphia, PA

11:20 am
Update from the NIH
Thaddeus Schug, PhD - National Institute of Environmental Health Sciences

11:35 am
Concluding Remarks & Acknowledgments
Wei Yan, MD, PhD - The Lundquist Institute at Harbor-UCLA/UCLA, Torrance, CA

11:50 am
Announcement of the XXVIIth North American Testis Workshop
Kate Loveland, PhD- Monash University and Hudson Institute, Melbourne, Australia