Program Chair: Wei Yan, MD, PhD Speaker: 8:00 am 8:05 am 8:55 am 9:00 am 9:40 am 10:20 am 10:40 am 11:20 am 11:35 am 1:10 pm 1:15 pm 1:55 pm 2:35 pm 2:55 pm 3:35 pm 3:50 pm 8:00 am 8:05 am 8:55 am 9:00 am 9:40 am 10:20 am 10:40 am Some Assembly Required: How to Build a Meiotic DNA-Breaking Machine 11:20 am 11:35 am 1:10 pm 1:15 pm 1:55 pm 2:35 pm 2:55 pm 3:35 pm 3:50 pm 8:00 am 8:05 am 8:55 am 9:00 am 9:40 am 10:20 am 10:40 am 11:20 am 11:35 am 11:50 amSchedule
Wednesday, May 4, 2022
Welcome and Opening Remarks
The Lundquist Institute at Harbor-UCLA/UCLA, Torrance, CAKEYNOTE ADDRESS: Where Are We in the Development of Non-hormonal Male Contraceptives?
Martin M. Matzuk, MD, PhD
Baylor College of Medicine, Houston, TX
Thursday, May 5, 2022
BENCHMARK LECTURE I
Introduction
Chair: Kate Loveland, PhD - Monash University and Hudson Institute, Melbourne, Australia
Lumicrine Factors in the Regulation of Spermatogenesis
Masahito Ikawa, PhD -Osaka University, Osaka, JapanSESSION I: NEW KIDS ON THE BLOCK: NOVEL FACTORS THAT REGULATE SPERMATOGENESIS (1)
Introduction to Session I
Chairs: Erwin Goldberg, PhD - Northwestern University
Penny Whiley, Hudson Institute of Medical Research
Everything Old is New Again: Redefining Protamine Structure and Function
Sue Hammoud, PhD - University of Michigan, Ann Arbor, MI
Identification of a Novel Germ Cell Granule with Potential Roles in Meiotic Germ Cell Translation
Elizabeth Snyder, PhD - University of Rutgers, New Brunswick, NJ
BREAK
Pachytene piRNAs in Germ Cell Development
Chen Chen, PhD - Michigan State University, East Lansing, MI
Short Talk #1: TENT4A and TENT4B Control Poly(A) Tail Length and Non-A Contents in Murine Spermatogenic Cells
Zhuqing Wang, PhD - The Lundquist Institute at Harbor-UCLA, Torrence, CA
Short Talk #2: In Pro-Spermatogonia the RNA Binding Protein DND1 Targets Transcripts for Epigenetic, Cell Cycle, and Translation Regulation
Victor Ruthig, PhD - Duke University Medical Center, Durham, NCSESSION II: NEW KIDS ON THE BLOCK: NOVEL FACTORS THAT REGULATE SPERMATOGENESIS (2)
Introduction to Session II
Chairs: Jon Oatley, PhD, Washington State University
Tessa Lord, PhD - University of Newcastle
New Ideas on Fertility Preservation for People with Testes
Kyle Orwig, PhD - University of Pittsburgh, Pittsburgh, PA
What Spermatogonial Stem Cells Can Tell Us About Molecular Networks, Infertility, and Selfish DNA
Miles Wilkinson, PhD - University of California, San Diego
BREAK
Sperm-like Stem Cell-mediated Genome Editing
Jinsong Li, PhD - Chinese Academy of Sciences, Shanghai, China
Short Talk #3: A Master Transcription Factor Influencing Both Pro-Spermatogonia and SSC Differentiation
Kun Tan, PhD - University of California, San Diego, San Diego, CA
Short Talk #4: Embryonic Origin of Testicular Macrophages
Andreas Meinhardt, PhD - Justus-Liebig University of Giessen, Giessen, Germany
Friday, May 6, 2022
BENCHMARK LECTURE II
Introduction
Chair: Michael Griswold, PhD, Washington State University
Why is the Sperm Proteome Modified in the Female Reproductive Tract?
Mariana Wolfner, PhD - Cornell University, Ithaca, NYSESSION III: BACK TO THE BASICS: REGULATION OF SPERMATOGENESIS (1)
Introduction to Session III
Chairs: Eirka Matunis, PhD, Johns Hopkins University
Hayden McSwiggin, PhD Candidate - The Lundquist Institute at Harbor-UCLA
New Insights into Sertoli Cell Fate Determination and Maintenance
Humphrey Yao, PhD - NIEHS, Research Triangle, NC
Epigenetic Regulation of Spermatogonial Stem Cell Specification
John McCarrey, MS, PhD - University of Texas, San Antonio, TX
BREAK
Scott Keeney, PhD - Sloan Kettering Cancer Center, New York, NY
Short Talk #5: Spatial Dynamics of Protein Translation in Sertoli Cells
Ana Cristina Lima, PhD - Oregon Health & Science University, Beaverton, OR
Short Talk #6: Chromatin States During Spermatogonial Differentiation
Christine Schleif, Master Graduate Student - Washington State University, Pullman, WASESSION IV: BACK TO THE BASICS: REGULATION OF SPERMATOGENESIS (2)
Introduction to Session IV
Chairs: Qi Chen, MD, PhD, University of California - Riverside
Kien Tran, PhD Candidate, University of Pittsburgh
Novel Transcription Factors Regulating Spermatogenesis
Prabhakara Reddi, PhD - University of Illinois Urbana-Champaign, Urbana, IL
Testosterone Recovery Therapy Targeting Dysfunctional Leydig Cells
Vassilios Papadopoulos, PharmD, PhD - University of Southern California, Los Angeles, CA
BREAK
Follicle-Stimulating Hormone and D-cyclins Regulate Male Germ Cell Maintenance
T. Rajendra Kumar, PhD - University of Colorado, Aurora, CO
Short Talk #7: Leydig Cell Regeneration in Adult Mouse Testes
Jasmin Jeffrey, BS, PhD Candidate - Johns Hopkins University School of Medicine, Baltimore, MD
Short Talk #8: Higher Incidence of Embryonic Defects in Offspring Conceived by Assisted Reproduction from Fathers with Sperm Epimutations
Gurbet Karahan, PhD - McGill University, Montreal, QC, Canada
Saturday, May 7, 2022
BENCHMARK LECTURE III
Introduction
Chair: Monika Ward, PhD, University of Hawaii
Paternal Epigenome and Offspring Health
Jacquetta Trasler, MD, PhD - McGill University, Montreal, CanadaSESSION V: ON TOP OF GENETICS - TESTICULAR EPIGENOME AND OFFSPRING HEALTH
Introduction to Session V
Chairs: Wenfeng An, PhD, South Dakota State University
Jasmin Jeffery, PhD Candidate, Johns Hopkins University
Sperm-mediated Transgenerational Inheritance
Corrado Spadafora, PhD - National Research Council of Italy, Rome, Italy
Sperm RNA-mediated Epigenetic Inheritance
Isabelle Mansuy, Ph.D. - University and ETH Zurich, Zurich, Switzerland
BREAK
Short and Long-term Effects of Male Germline Reprogramming in the Absence of TET1
Marisa Bartolomei, PhD - University of Pennsylvania, Philadelphia, PA
Update from the NIH
Thaddeus Schug, PhD - National Institute of Environmental Health Sciences
Concluding Remarks & Acknowledgments
Wei Yan, MD, PhD - The Lundquist Institute at Harbor-UCLA/UCLA, Torrance, CA
Announcement of the XXVIIth North American Testis Workshop
Kate Loveland, PhD- Monash University and Hudson Institute, Melbourne, Australia